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翰林國際學術活動流程

iGEM國際基因工程機器大賽輔導

?一個關于合成生物學的世界頂級賽事

為什么參加IGEM?

全球最高水平的全成生物學學術學術活動
最受美國名校青睞的學術學術活動之一
學術活動機制涵蓋生物、數學、計算機、機械電子工程設計等多學科
與世界各地名校隊伍同臺競技，全面提高綜合素質，開拓國際視野
浙大、武大等頂尖雙一流高校教授全程指導
專職名校博士團隊傾力帶隊指導

IGEM學術活動輔導

1.基礎教學

（1）科學思維與學術研究導論
（2）合成生物學及基理論基礎課程
（3）IGEM學術活動規則指導
（4）IGEM學術活動團隊領導力課程（中學基因工程學術社團指導）
（5）基因工程基礎實驗
（6）生物信息學習與數學建模

2.實驗指導

（1）命題討論與聚焦
（2）命題設計與實驗設計指導
（3）實驗操作指導
（4）數據處理與建模指導
（5）論文寫作指導
（6）學術答辯指導

3.社會活動
（1）課題的公眾宣傳
（2）社會調研（企業、社區）
（3）學者調研（教授、院士、醫生）
（4）與其他參賽隊的互助實驗
（5）贊助方案與眾籌指導

4.項目展示
（1）海報、PPT設計
（2）項目展示頁面（WIKI）設計
（3）演講與答辯技巧指導

參賽指導
（1）赴美參賽的后勤保障
（2）比賽臨場指導

iGEM參賽時間安排表

時間	內容
1-2月	賽前冬令營集訓
3月	每周末線上培訓，講解近期論文和往屆優秀項目。組織1次線下周末活動，探討項目，撰寫可行性方案。設計第一批生物磚。
4月	周末線上培訓。文獻閱讀和討論。組織1次周末實驗，確定項目，確定DNA parts，訂購引物。進行預實驗構建第一批生物磚。
5月	每周末線上交流，文獻閱讀和討論。查閱資料，完善項目背景。開展有關項目背景的human practice 組織1次周末實驗，測試實驗條件。
6月	每周末線上交流，文獻閱讀和討論。暑假前，組織學生1-2次周末實驗，獲取數據。
7月	進實驗室做實驗，獲取實驗數據。進行數學建模訓練。
8月	進實驗室做實驗，獲取實驗數據。組織學生參與隊伍交流。
9月	協助學生整理實驗數據，完成wiki框架和背景內容。完成ppt草稿進行與項目展示相關的human practice
10月	每周線上交流。整理wiki，poster，訓練ppt展示。比賽前邀請優秀的科學家評委，安排1-2次ppt答辯
11月	賽前準備，赴美比賽

?申請條件

（1）高一、高二在校學生（每隊8-15名）
（2）具備良好的英文聽說讀寫能力
（3）具有團隊溝通、協作與表達能力
（4）對研究性學習有著濃厚的興趣、希望培養自已獨立思考、分析與解決問題的能力
（5）有一定的實驗、美術設計、編程、建模、攝影、英文等基礎將成為加分項

報名及面試流程

1.學生填寫報名表。
2.導師對申請者進行審核。通過審核后，學生需參加面試。
3.學生通過面試后簽訂科研指導協議，并支付參賽輔導費、報名費、實驗室使用費、海外參賽費。
4.付費后，學員將收到錄取通知、實驗室報到通知，課程計劃以及預習資料包。

2018-2019IGEM獲獎作品部分展示（共9隊）

1.? 隊名：Great Bay China

項目名稱：microbial Compartmentalization AssisTed Nepetalactol Ingredient Production

獎項：

（1）Grand Prize Winner
（2）Best Wiki
（3）Best Poster
（4）Best Model
（5）Best New Composite Part
（6）Best Part Collection
（7）Best Product Design
（8）Best New Basic Part

摘要/項目介紹：

Nepetalactone is the active ingredient in catnip, a feline attractant, and a potential green pesticide. It has a common precursor, nepetalactol, with monoterpene indole alkaloids (MIAs) which is a group of plant-derived compounds of great therapeutic value, such as vincristine (an anti-cancer drug). We aim to synthesize nepetalactol through a mutualistic division of labour between E. coli and yeast. Besides, we design, characterize, and use a library of transcription activator-like effectors (TALE)stabilized promoters to regulate the heterologous gene expression in E. coli. Our applied design conceives the future application of nepetalactone on stray cat control, which we consider as an opportunity for public engagement and education.

2. 隊名：GreatBay_SZ

項目名稱：SPIDERMAN_SPIDroin EngineeRing with chroMoprotein And Natural dye

獎項：

（1）Grand Prize Winner;
（2）Best Education and Public Engagement;
（3）Best Hardware;
（4）Best Integrated Human Practices;
（5）Best Measuremen;
（6）Best Model;
（7）Best New Basic Part;
（8）Best New Composite Part;
（9）Best Part Collection;
（10）Best Poster;
（11）Best Presentation;
（12）Best Wiki;
（13）iGEMers' Prize

摘要/項目介紹：

Spider silk serves as a new material with superior properties that can be applied in medication, cloth, and aerospace fields. However, spider breeding is not applicable due to spider's fierce behavior. The current approach is to produce recombinant spidroins (silk proteins) from other chassis and spin them into silk. This year , we aim to manufacture recombinant spider silk with E.coli and color the silk for application in cloth industry. We modularized three significant domains of spidroin - the N-terminal, the repetitive region, and the C-terminal - and integrated them into various spidroin to form silk. We then dyed the silk with microbial natural pigments deoxyviolacein and indigo. To obtain better color and a more convenient dying process, we fused the repetitive region to chromoproteins and mixed them with spidroin during spinning. Our team hopes to provide a novel approach for cloth production and explore new possibilities for spider silk applications.

3. 隊名：Mingdao

項目名稱：Fresh Air, the clever heir

獎項：

（1）Best Education and Public Engagement;
（2）Best Integrated Human Practices;
（3）Best Model;
（4）Best New Basic Part;
（5）Best New Composite Part;
（6）Best Part Collection;
（7）Best Poster;
（8）Best Supporting Entrepreneurship;
（9）Best Wiki

摘要/項目介紹：

To increase our algae system's efficiency of reducing indoor pollutants such as CO2 and VOCs, we applied two enzymes, carbonic anhydrase(CA) and cytochrome P450 2E1(CYP2E1) to improve algal absorption of CO2 and VOCs, respectively. We produced enzymes by engineering Bacillus subtilis 168 with BioBricks we created and then finally put them into our system. We also did some experiments to analyze the activity of our enzymes and test whether our system is efficient enough to refresh indoor air.

4. 隊名：GENAS_China

項目名稱：Recombinase-Based Biological Relay devices (RBBR),

獎項：

（1）Best Measuremen;
（2）Best Model;
（3）Best New Basic Part;
（4）Best Part Collection;Best Wiki

摘要/獎項介紹：

Generally, the relay, the key component of electrical automatic control system, receives the output signal of a control module and thus shifts the ON/OFF state of a separated working module. Based on the recombinase-attB/attP system and unidirectional terminator, we constructed a set of orthogonal Recombinase-Based Biological Relay devices (RBBR), whose response intervals were characterized by accurate quantifying method so that they can be predictably adapted to different genetic circuits. We designed and constructed a resolution extensible analog-digital converter (ADC), which converts the consecutive analog quantities (the strength of an inducible promoter) into discrete digital signals (indicated by different chromoproteins), allowing the digitized processing and storage of signals. Beyond the common use of recombinase system as simple response to two input levels, our project achieves modifying and utilizing the response interval of this system. The application of relay in genetic circuit can contribute to the improvement of the modularity of artificial biological system.

5. 隊名：US_AFRL_CarrollHS

項目名稱：ENGINEERING A CELL-FREE HEXAVALENT CHROMIUM DETECTION SYSTEM

獎項：Best Education and Public Engagement

摘要/項目介紹：

Methylophaga flavin-containing monooxygenase (bFMO) is the gene responsible for the conversion of the Indole into Isatin, which is then catalyzed into indigoid compounds. These compounds display an indigo color which can be easily detected (KAIST). Our project will focus on using bFMO as indicator to determine when toxic hexavalent chromium is present. The bFMO will be cloned into the C4-HSL circuit created by our team last year, in order to show the indigo color can be produced and easily seen. This will be done by replacing GFPa1 (green fluorescent protein) with the bFMO gene. Next, bFMO will be cloned into a construct with a T7 promoter, which we believe will be the most efficient promoter for bFMO. This construct will then be tested to ensure that the promoter will produce bFMO. Once this is done, the chrB repressor will be introduced. In order to determine when hexavalent chromium is present, a repressor, chrB, will be cloned into a construct along with the promoter, chrP, associated with the repressor. This construct will then be cloned into a pet11a backbone, which already has both the T7 promoter and rbs needed. The plasmid should then produce chrB, which will disrupt the chrP causing bFMO to not be produced. A commercial cell-free extract kit will then be used on this construct, and the T7-chrB plasmid will be added in order to make ChrB. When chromium is detected the ChrB repressor will be ‘knocked off,’ allowing the promoter to function and bFMO to catalyze into indigoid compounds, emitting a detectable indigo color.

6. 隊名：SHSBNU_China

項目名稱：/

獎項：Best New Composite Part

摘要/項目介紹：

DNA is a biological macro-molecule which can carry huge amount of information accurately, and this feature can be used to achieve data recordings in vivo. Our project aims to build a biological recorder that can monitor extracellular information and record it on DNA. Recombinase or CRISPR base-editor is used to target specific DNA addresses and generate mutations in a reporter gene, so the recordings can be quantitatively measured to infer intensity and duration information about the chemicals of disease, such as inflammatory bowel disease. Additionally, we designed a hardware for in situ biomolecular detection to monitor gastrointestinal health. This platform could enable more precise detection and could help improve the management and diagnosis of gastrointestinal disease.

7. 隊名：Greatbay_SCIE

項目名稱：Stickit

獎項：Best Part Collection

摘要/項目介紹：

To create a well-functioning adhesive, cohesion--the ability to maintain the shape of the material--and adhesion--the ability to stick to underwater surfaces--should cooperate. Our toolbox consists of several groups of biological parts from marine creatures (mussel and barnacles) and prokaryotes (E.coli MG1655 and Marine Archaea). These proteins will provide cohesion, adhesion, and other special qualities. We will then combine these proteins using principles of synthetic biology to create protein adhesives with high-performance and biocompatibility. Their potentials are limitless and can be applied to many fields.

8. 隊名：TAS_Taipei

項目名稱：ADIEU, RESIDUES!

獎項：Best Part Collection

摘要/項目介紹：

We consume fruits and vegetables every day without knowing whether or not agricultural residues (i.e. pesticides & heavy metals) are present. In 2017, according to the UN, exposure to pesticides caused 200,000 to 300,000 deaths annually. Additionally, lead exposure alone is responsible for a death rate of 25.3 per 100,000 individuals in East Asia. Current methods of agricultural residue detection are not easily accessible to the public and are inconvenient for everyday use. Thus, our project aims to allow for convenient visualization of agricultural residues by designing colored proteins that can directly interact with these residues. We envision a system where our designed proteins can be applied directly on food items to detect the presence of residues. Our final product can be used by consumers, distributors and farmers alike.

9. 隊名：TPHS_San_Diego

項目名稱：Breakdown of Trimethylamine via Trimethylamine Dehydrogenase to Minimize Heart Disease Caused by Red Meat Consumption

獎項：Best Plant Synthetic Biology

摘要/項目介紹：

The consumption of red meat has been linked to atherosclerosis, a form of heart disease caused by the buildup of plaque in the arteries. Recently, it was discovered that the combination of choline and L-carnitine from red meat, are converted to trimethylamine (TMA) in the body. TMA is a precursor to trimethylamine N-oxide (TMAO), which is found to exacerbate cholesterol buildup, ultimately leading to atherosclerosis. In this study, we targeted this pathway by breaking down the precursor, TMA, before TMAO is formed. A system designed to concurrently degrade TMA and subdue its toxic by-product, formaldehyde, was implemented in E. coli for these purposes. This system is composed of Trimethylamine Dehydrogenase (TMADH) and Formaldehyde Dehydrogenase (FDH) which are being tested independently for their degradation properties. Our approach has proven that TMADH is effective in TMA degradation and FDH can be expressed in a bacterial vector to minimize the presence of formaldehyde.